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RL-SKAT: An Exact and Efficient Score Test for Heritability and Set Tests.

Genetics - 1 Dec 2017

Schweiger Regev, Weissbrod Omer, Rahmani Elior, Müller-Nurasyid Martina, Kunze Sonja, Gieger Christian, Waldenberger Melanie, Rosset Saharon, Halperin Eran

Abstract excerpt

Testing for the existence of variance components in linear mixed models is a fundamental task in many applicative fields. In statistical genetics, the score test has recently become instrumental in the task of testing an association between a set of genetic markers and a phenotype. With few markers, this amounts to set-based variance component tests, which attempt to increase power in association studies by...

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PMID: 29025915
DOI: 10.1534/genetics.117.300395
PMCID: PMC5714447

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