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Article

USAT: A Unified Score-Based Association Test for Multiple Phenotype-Genotype Analysis.

Genetic epidemiology - 1 Jan 2016

Ray Debashree, Pankow James S, Basu Saonli

Abstract excerpt

Genome-wide association studies (GWASs) for complex diseases often collect data on multiple correlated endo-phenotypes. Multivariate analysis of these correlated phenotypes can improve the power to detect genetic variants. Multivariate analysis of variance (MANOVA) can perform such association analysis at a GWAS level, but the behavior of MANOVA under different trait models has not been carefully investigated. In...

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PMID: 26638693
DOI: 10.1002/gepi.21937
PMCID: PMC4785800

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