Causal association between smoking behavior and the decreased risk of osteoarthritis: a Mendelian randomization.

Abstract excerpt

OBJECTIVE: This study aimed to examine whether smoking behavior is causally associated with osteoarthritis. METHODS: A two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods was performed. We used the publicly available summary statistics datasets of smoking behavior genome-wide association studies (GWASs; n = 85,997) as an...

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