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Article

Causal effects of modifiable risk factors on obstructive sleep apnea: A Mendelian randomization study and validation study.

Medicine - 16 Jan 2026

Li Zhen

Abstract excerpt

Obstructive sleep apnea (OSA) is a chronic condition characterized by recurrent upper airway obstruction during sleep. The pathogenesis of OSA remains unclear, and few studies have systematically investigated causal associations with modifiable risk factors at the genetic level. This study used Mendelian randomization (MR) based on genome-wide association study (GWAS) data to evaluate potential causal effects of...

Topics

Humans
Sleep Apnea, Obstructive
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide
Genome-Wide Association Study
Risk Factors
Body Mass Index
Cross-Sectional Studies
Male
Female
Nutrition Surveys

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41559995
DOI: 10.1097/MD.0000000000046771
PMCID: PMC12826191

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41559995-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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