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Article

Causal relationship between periodontal disease-related phenotype and knee osteoarthritis: A two-sample mendelian randomization analysis.

PloS one - 1 Jan 2024

Shen Longqiang, Niu Di, Deng Gang

Abstract excerpt

OBJECTIVE: This study aimed to explore the bidirectional causal relationship between periodontal disease-related phenotype (PDRP) and knee osteoarthritis (KOA) in a European population using a two-sample Mendelian Randomization (MR) approach. METHODS: We leveraged publicly available GWAS summary statistics for PDRP (n = 975) and KOA (n = 403,124), assessing their roles as both exposures and outcomes. Our...

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Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis
Osteoarthritis, Knee
Periodontal Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Identifiers

PMID: 38820296
DOI: 10.1371/journal.pone.0304117
PMCID: PMC11142551

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