Article
Assessment of causal effects of physical activity on the risk of osteoarthritis: a two-sample Mendelian randomization study.
BMC medical genomics - 9 Oct 2023
Wang Bin, Liu Yang, Zhang Yao-Chen, Han Zi-Yi, Hou Jia-Lin, Chen Shuai, Xiang Chuan
Abstract excerpt
BACKGROUND: Growing evidence supports an association between physical activity (PA) and the risk of osteoarthritis (OA), but this may be influenced by confounding and reverse causality. Therefore, we performed a two-sample Mendelian randomization (MR) analysis to reveal the causal relationship between PA and OA. METHODS: MR was performed to explore the causation of PA and OA with genetic variants as instrumental...
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