Article
Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism.
Molecular psychiatry - 1 May 2012
Villafuerte S, Heitzeg M M, Foley S, Yau W-Y Wendy, Majczenko K, Zubieta J-K, Zucker R A, Burmeister M
Abstract excerpt
Genetic factors, externalizing personality traits such as impulsivity, and brain processing of salient stimuli all can affect individual risk for alcoholism. One of very few confirmed genetic association findings differentiating alcoholics from non-alcoholics is with variants in the inhibitory γ-amino butyric acid α2 receptor subunit (GABRA2) gene. Here we report the association of two of these GABRA2 variants...
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