Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of drug resistance mutations in whole blood DNA from HIV-1 infected patients by single genome and ultradeep sequencing analysis.

Journal of virological methods - 1 Oct 2018

Sotillo Alma, Sierra Olalla, Martínez-Prats Lorena, Gutiérrez Francisca, Zurita Sagrario, Pulido Federico, Rubio Rafael, Delgado Rafael

Abstract excerpt

In HIV-1 infected patients blood CD4+ T lymphocytes could be a valuable target to analyse drug resistance mutations (DRM) selected over the course of the infection. However, detection of viral resistance mutations in cellular DNA by standard genotype resistance techniques (SGRT) is suboptimal. Whole blood DNA (wbDNA) from 12 HIV-1 infected patients on ART was studied by Single Genome Sequencing (SGS) and 8 of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-HIV Agents
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Viral

Share to Drug Resistance, Viral

Share to Genome, Viral

Share to HIV Infections

Share to Proviruses

Share to Virus Integration

Source

Identifiers

PMID: 29969601
DOI: 10.1016/j.jviromet.2018.06.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of drug resistance mutations in whole blood DNA from HIV-1 infected patients by single genome and ultradeep sequencing analysis.PMID 29969601Read ↗

Ultra-deep sequencing improves the detection of drug resistance in cellular DNA from HIV-infected patients on ART with suppressed viraemia.Semantic proximity Read ↗

Sensitive HIV-1 DNA Pol Next-Generation Sequencing for the Characterisation of Archived Antiretroviral Drug Resistance.Semantic proximity Read ↗

New Aspects of the Virus Life Cycle and Clinical Utility of Next Generation Sequencing based HIV-1 Resistance Testing in the Genomic, the Proviral, and the Viral Reservoir of Peripheral Blood Mononuclear Cells.Semantic proximity Read ↗

Dynamics of HIV-1 quasispecies during antiviral treatment dissected using ultra-deep pyrosequencing.Semantic proximity Read ↗

Comparison of short-read and long-read next-generation sequencing technologies for determining HIV-1 drug resistance.Semantic proximity Read ↗

HIV DNA Sequencing to Detect Archived Antiretroviral Drug ResistanceSemantic proximity Read ↗

Profiling resistance-related mutations in the protease region of the pol gene: single genome sequencing of HIV in plasma and peripheral blood mononuclear cells.Semantic proximity Read ↗

Clinical impact of ultra deep versus Sanger sequencing detection of minority mutations on HIV-1 drug resistance genotype interpretation after virological failureSemantic proximity Read ↗

The relevance of ultradeep sequencing for low HIV-1 viral loads and proviruses in the clinical setting.Semantic proximity Read ↗

Detecting primary drug-resistant mutations in Korean HIV patients using ultradeep pyrosequencing.Semantic proximity Read ↗

Comparison of HIV-1 drug-resistance genotyping by ultra-deep sequencing and sanger sequencing using clinical samples.Semantic proximity Read ↗

Sanger and Next Generation Sequencing Approaches to Evaluate HIV-1 Virus in Blood Compartments.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.