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Article

Sanger and Next Generation Sequencing Approaches to Evaluate HIV-1 Virus in Blood Compartments.

International journal of environmental research and public health - 9 Aug 2018

Arias Andrea, López Pablo, Sánchez Raphael, Yamamura Yasuhiro, Rivera-Amill Vanessa

Abstract excerpt

The implementation of antiretroviral treatment combined with the monitoring of drug resistance mutations improves the quality of life of HIV-1 positive patients. The drug resistance mutation patterns and viral genotypes are currently analyzed by DNA sequencing of the virus in the plasma of patients. However, the virus compartmentalizes, and different T cell subsets may harbor distinct viral subsets. In this...

Topics

Adult
Drug Resistance, Viral
HIV Infections
HIV-1
High-Throughput Nucleotide Sequencing
Humans
Leukocytes, Mononuclear
Male
Mutation
Sequence Analysis, DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30096879
DOI: 10.3390/ijerph15081697
PMCID: PMC6122037

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