Article
Profiling resistance-related mutations in the protease region of the pol gene: single genome sequencing of HIV in plasma and peripheral blood mononuclear cells.
AIDS research and human retroviruses - 1 Jul 2008
Guimarães Ana Paula, Sa-Filho Dercy Jose, Sucupira Maria Cecilia, Janini Luiz Mario, Diaz Ricardo Sobhie
Abstract excerpt
Genotypic resistance is currently assessed through direct sequencing, which cannot detect resistant strains below 20%. We compared the genotypic resistance profile of virions and proviruses using population-based analysis and single genome sequencing of the protease region of the pol gene in samp...
Topics
- Amino Acid Sequence
- Drug Resistance, Viral
- HIV
- HIV Infections
- HIV Protease
- HIV Protease Inhibitors
- Humans
- Indinavir
- Leukocytes, Mononuclear
- Molecular Sequence Data
- Mutation
- Plasma
- Proviruses
- Sequence Alignment
- Treatment Failure
- Virion