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Article

Recent advances in Wilms' tumor predisposition.

Human molecular genetics - 20 Oct 2020

Maciaszek Jamie L, Oak Ninad, Nichols Kim E

Abstract excerpt

Wilms' tumor (WT), the most common childhood kidney cancer, develops in association with an underlying germline predisposition in up to 15% of cases. Germline alterations affecting the WT1 gene and epigenetic alterations affecting the 11p15 locus are associated with a selective increase in WT risk. Nevertheless, WT also occurs in the context of more pleiotropic cancer predispositions, such as DICER1, Li-Fraumeni...

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Identifiers

PMID: 32412586
DOI: 10.1093/hmg/ddaa091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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