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Article

Huntington’s Disease Protein Huntingtin Associates with its own mRNA

31 Mar 2016

Abstract excerpt

BACKGROUND: The Huntington's disease (HD) protein huntingtin (Htt) plays a role in multiple cellular pathways. Deregulation of one or more of these pathways by the mutant Htt protein has been suggested to contribute to the disease pathogenesis. Our recent discovery-based proteomics studies have uncovered RNA binding proteins and translation factors associated with the endogenous Htt protein purified from mouse...

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PMID: 26891106
DOI: 10.3233/jhd-150177

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