Article
The role of next-generation sequencing in the differential diagnosis of composite neoplasms.
Human pathology - 1 Nov 2018
Acosta Andres Martin, Al Rasheed Mohamed R H, Pins Michael R, Borgen Kristina R, Panchal Dipti, Rogozinska Magdalena, Wiley Elizabeth L, Behm Frederick G, Mohapatra Gayatry
Abstract excerpt
Composite neoplasms (CNs) are rare and diagnostically challenging lesions that require differentiating between mixed clonal tumors with divergent phenotypes (MT), collision of 2 independent tumors adjacent to each other (CT), and tumor-to-tumor metastasis (TTM). To that end, pathologists have traditionally used immunohistochemistry and limited molecular studies, such as Sanger sequencing. Herein we evaluate the...
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