Article
Molecular Profiling of Multiple Primary Merkel Cell Carcinoma to Distinguish Genetically Distinct Tumors From Clonally Related Metastases.
JAMA dermatology - 1 Jun 2017
Harms Kelly L, Lazo de la Vega Lorena, Hovelson Daniel H, Rahrig Samantha, Cani Andi K, Liu Chia-Jen, Fullen Douglas R, Wang Min, Andea Aleodor A, Bichakjian Christopher K, Johnson Timothy M, Tomlins Scott A, Harms Paul W
Abstract excerpt
Importance: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma. In rare cases, the development of an additional cutaneous MCC tumor is clinically consistent with a second primary MCC tumor rather than a cutaneous metastasis, which has important treatment and prognostic implications. Objective: To evaluate genetic relatedness in 4 cases with the clinical diagnosis of multiple primary...
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