Targeted Next-Generation Sequencing Reveals Divergent Clonal Evolution in Components of Composite Pleomorphic Xanthoastrocytoma-Ganglioglioma.

doi:10.1093/jnen/nlac044

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Article

Targeted Next-Generation Sequencing Reveals Divergent Clonal Evolution in Components of Composite Pleomorphic Xanthoastrocytoma-Ganglioglioma.

Journal of neuropathology and experimental neurology - 19 Jul 2022

Lucas Calixto-Hope G, Davidson Christian J, Alashari Mouied, Putnam Angelica R, Whipple Nicholas S, Bruggers Carol S, Mendez Joe S, Cheshier Samuel H, Walker Jeffrey B, Ramani Biswarathan, Cadwell Cathryn R, Sullivan Daniel V, Lu Rufei, Mirchia Kanish, Van Ziffle Jessica, Devine Patrick, Goldschmidt Ezequiel, Hervey-Jumper Shawn L, Gupta Nalin, Oberheim Bush Nancy Ann, Raleigh David R, Bollen Andrew, Tihan Tarik, Pekmezci Melike, Solomon David A, Phillips Joanna J, Perry Arie

Abstract excerpt

Composite pleomorphic xanthoastrocytoma-ganglioglioma (PXA-GG) is an extremely rare central nervous system neoplasm with 2 distinct but intermingled components. Whether this tumor represents a "collision tumor" of separate neoplasms or a monoclonal neoplasm with divergent evolution is poorly understood. Clinicopathologic studies and capture-based next generation sequencing were performed on extracted DNA from all...

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PMID: 35703914
DOI: 10.1093/jnen/nlac044
PMCID: PMC9297094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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