Article
Single-cell paired-end genome sequencing reveals structural variation per cell cycle.
Nucleic acids research - 1 Jul 2013
Voet Thierry, Kumar Parveen, Van Loo Peter, Cooke Susanna L, Marshall John, Lin Meng-Lay, Zamani Esteki Masoud, Van der Aa Niels, Mateiu Ligia, McBride David J, Bignell Graham R, McLaren Stuart, Teague Jon, Butler Adam, Raine Keiran, Stebbings Lucy A, Quail Michael A, D'Hooghe Thomas, Moreau Yves, Futreal P Andrew, Stratton Michael R, Vermeesch Joris R, Campbell Peter J
Abstract excerpt
The nature and pace of genome mutation is largely unknown. Because standard methods sequence DNA from populations of cells, the genetic composition of individual cells is lost, de novo mutations in cells are concealed within the bulk signal and per cell cycle mutation rates and mechanisms remain...
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