Article

Conbase: a software for unsupervised discovery of clonal somatic mutations in single cells through read phasing

2018-02-05

Abstract excerpt

Here we report the development of Conbase, a software application for the identification of somatic mutations in single cell DNA sequencing data with high rates of allelic dropout and at low read depth. Conbase leverages data from multiple samples in a dataset and utilizes read phasing to call somatic single nucleotide variants and to accurately predict genotypes in whole genome amplified single cells in somatic v...

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Literature Corpus work: 4681790a-6d7e-568c-b588-dc7058686ad0
DOI: 10.1101/259994

Open publication

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