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Solubis: a webserver to reduce protein aggregation through mutation.

Protein engineering, design & selection : PEDS - 1 Aug 2016

Van Durme Joost, De Baets Greet, Van Der Kant Rob, Ramakers Meine, Ganesan Ashok, Wilkinson Hannah, Gallardo Rodrigo, Rousseau Frederic, Schymkowitz Joost

Abstract excerpt

Protein aggregation is a major factor limiting the biotechnological and therapeutic application of many proteins, including enzymes and monoclonal antibodies. The molecular principles underlying aggregation are by now sufficiently understood to allow rational redesign of natural polypeptide sequences for decreased aggregation tendency, and hence potentially increased expression and solubility. Given that...

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PMID: 27284085
DOI: 10.1093/protein/gzw019

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