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Article

Mitochondrial genome analysis in penile carcinoma.

Molecular biology reports - 1 Aug 2018

Araujo L F, Terra A T, Sares C T G, Sobreira C F R, Faria E F, Machado R D, Rodrigues A A, Muglia V F, Silva W A, Reis R B

Abstract excerpt

Penile cancer is a rare neoplasm that seems to be linked to socio-economic differences. Mitochondrial genome alterations are common in many tumors types and are reported as regulating oxidative metabolism and impacting tumorigenesis. In this study, we evaluate for the first time the mitochondrial genome in penile carcinoma (PeCa), aiming to evaluate heteroplasmy, mitochondrial DNA (mtDNA) mutational load and...

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Identifiers

PMID: 29948632
DOI: 10.1007/s11033-018-4197-5

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