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Distinct Mutation Signatures in Peripheral Blood Mitochondrial DNA from Liquid Biopsy Reveal Insights into Pancreatic Cancer.

Cells - 16 Mar 2026

Randeu Hannah, Bronkhorst Abel, Oberhofer Angela, Worf Karolina, Uhlig Carsten, Polatoglou Eleni, Mayer Zsuzsanna, Dorman Klara, Zhang Danmei, Boeck Stefan, Heinemann Volker, Haas Michael, Holdenrieder Stefan

Abstract excerpt

Pancreatic cancer (PC) is a highly aggressive malignancy characterized by limited opportunities for early diagnosis and poor clinical outcomes, underscoring the need for minimally invasive biomarkers to improve detection and patient stratification. Given emerging evidence that mitochondrial DNA (mtDNA) alterations reflect cancer-related biological processes, this study investigated whether blood-derived mtDNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41892318
DOI: 10.3390/cells15060527
PMCID: PMC13025575

Genes

PC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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