Article
MED12 is frequently mutated in ovarian and other adnexal leiomyomas.
Human pathology - 1 Nov 2018
Li Zhuo, Maeda Daichi, Kudo-Asabe Yukitsugu, Tamura Daisuke, Nanjo Hiroshi, Hayashi Akimasa, Ikemura Masako, Fukayama Masashi, Goto Akiteru
Abstract excerpt
In the female genital tract, extrauterine leiomyomas such as those that arise in the ovary and paraovarian/paratubal regions are rare. Currently, little is known about the background genetic changes in such adnexal leiomyomas. Recent studies have found that the MED12 mutation is common in uterine leiomyomas, which suggests that such mutations may play an oncogenic role in smooth muscle neoplasms in females....
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