Article
Degradation of unmethylated miRNA/miRNA*s by a DEDDy-type 3' to 5' exoribonuclease Atrimmer 2 in Arabidopsis.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jul 2018
Wang Xiaoyan, Wang Yuan, Dou Yongchao, Chen Lu, Wang Junli, Jiang Ning, Guo Chunce, Yao Qingqing, Wang Chizao, Liu Lin, Yu Bin, Zheng Binglian, Chekanova Julia A, Ma Jinbiao, Ren Guodong
Abstract excerpt
The 3' end methylation catalyzed by HUA Enhancer 1 (HEN1) is a crucial step of small RNA stabilization in plants, yet how unmethylated small RNAs undergo degradation remains largely unknown. Using a reverse genetic approach, we here show that Atrimmer 2 (ATRM2), a DEDDy-type 3' to 5' exoribonuclease, acts in the degradation of unmethylated miRNAs and miRNA*s in Arabidopsis Loss-of-function mutations in ATRM2...
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