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Article

Covariate-modulated local false discovery rate for genome-wide association studies.

Bioinformatics (Oxford, England) - 1 Aug 2014

Zablocki Rong W, Schork Andrew J, Levine Richard A, Andreassen Ole A, Dale Anders M, Thompson Wesley K

Abstract excerpt

MOTIVATION: Genome-wide association studies (GWAS) have largely failed to identify most of the genetic basis of highly heritable diseases and complex traits. Recent work has suggested this could be because many genetic variants, each with individually small effects, compose their genetic architecture, limiting the power of GWAS, given currently obtainable sample sizes. In this scenario, Bonferroni-derived...

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PMID: 24711653
DOI: 10.1093/bioinformatics/btu145
PMCID: PMC4103587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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