Article
[Genetic variations in MLH3 and MSH2 genes are associated with the sensitivity and prognosis in locally advanced rectal cancer patients receiving preoperative chemoradiotherapy].
Zhonghua zhong liu za zhi [Chinese journal of oncology] - 23 Jun 2018
Yang J, Wang X, Zou S M, Li H M, Xiao Q, Feng Y R, Huang Y, Feng T, Chen J N, Lin D X, Li Y X, Jin J, Tan W
Abstract excerpt
Objective: To investigate the associations between genetic variations in DNA mismatch repair genes and sensitivity as well as prognosis to preoperative chemoradiotherapy in patients with locally advanced rectal cancer. Methods: Fourteen haplotype-tagging single nucleotide polymorphisms (htSNPs) of MLH1, MLH3 and MSH2 genes were genotyped by Sequenom MassARRAY method in 146 patients with locally advanced rectal...
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