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Article

Pharmacogenetics Biomarkers and Their Specific Role in Neoadjuvant Chemoradiotherapy Treatments: An Exploratory Study on Rectal Cancer Patients.

International journal of molecular sciences - 5 Sept 2016

Dreussi Eva, Cecchin Erika, Polesel Jerry, Canzonieri Vincenzo, Agostini Marco, Boso Caterina, Belluco Claudio, Buonadonna Angela, Lonardi Sara, Bergamo Francesca, Gagno Sara, De Mattia Elena, Pucciarelli Salvatore, De Paoli Antonino, Toffoli Giuseppe

Abstract excerpt

BACKGROUND: Pathological complete response (pCR) to neoadjuvant chemoradiotherapy (CRT) in locally advanced rectal cancer (LARC) is still ascribed to a minority of patients. A pathway based-approach could highlight the predictive role of germline single nucleotide polymorphisms (SNPs). The primary aim of this study was to define new predictive biomarkers considering treatment specificities. Secondary aim was to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27608007
DOI: 10.3390/ijms17091482
PMCID: PMC5037760

Genes

MSH6
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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