Article
The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice.
PloS one - 1 Jan 2012
Beucher Anthony, Gjernes Elisabet, Collin Caitlin, Courtney Monica, Meunier Aline, Collombat Patrick, Gradwohl Gérard
Abstract excerpt
Intestinal hormones are key regulators of digestion and energy homeostasis secreted by rare enteroendocrine cells. These cells produce over ten different hormones including GLP-1 and GIP peptides known to promote insulin secretion. To date, the molecular mechanisms controlling the specification of the various enteroendocrine subtypes from multipotent Neurog3(+) endocrine progenitor cells, as well as their number,...
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