Article
SONiCS: PCR stutter noise correction in genome-scale microsatellites.
Bioinformatics (Oxford, England) - 1 Dec 2018
Kedzierska Katarzyna Z, Gerber Livia, Cagnazzi Daniele, Krützen Michael, Ratan Aakrosh, Kistler Logan
Abstract excerpt
Motivation: Massively parallel capture of short tandem repeats (STRs, or microsatellites) provides a strategy for population genomic and demographic analyses at high resolution with or without a reference genome. However, the high Polymerase Chain Reaction (PCR) cycle numbers needed for target capture experiments create genotyping noise through polymerase slippage known as PCR stutter. Results: We developed...
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