STRsensor: a computationally efficient method for STR allele-typing from massively parallel sequencing data.

doi:10.1093/bib/bbae637

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Article

STRsensor: a computationally efficient method for STR allele-typing from massively parallel sequencing data.

Briefings in bioinformatics - 22 Nov 2024

Zhang Xiaolong, Ji Xianchao, Wang Lingxiang, Chi Lianjiang, Li Chengtao, Wen Shaoqing, Chen Hua

Abstract excerpt

Short tandem repeats (STRs) represent one of the most polymorphic variations in the human genome, finding extensive applications in forensics, population genetics and medical genetics. In contrast to the traditional capillary electrophoresis (CE) method, genotyping STRs using massive parallel sequencing technology offers enhanced sensitivity and accuracy. However, current methods are mainly designed for target...

Topics

Humans
High-Throughput Nucleotide Sequencing
Microsatellite Repeats
Alleles
Genome, Human
Whole Genome Sequencing
Software

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PMID: 39665493
DOI: 10.1093/bib/bbae637
PMCID: PMC11635639

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