Article
Relationship of polymorphisms in the tissue inhibitor of metalloproteinase (TIMP)-1 and -2 genes with chronic heart failure.
Scientific reports - 21 Jun 2018
Polina Evelise Regina, Araújo Raquel Rosa Candebat Vallejo, Sbruzzi Renan Cesar, Biolo Andréia, Rohde Luís Eduardo, Clausell Nadine, Dos Santos Kátia Gonçalves
Abstract excerpt
Dysregulated expression of tissue inhibitors of matrix metalloproteinases (TIMPs) is associated with systolic dysfunction and worsening heart failure (HF). However, no study has assessed the relationship between TIMP polymorphisms and chronic HF. In this study, 300 HF outpatients with reduced left ventricular ejection fraction and 304 healthy blood donors were genotyped for the 372 T > C polymorphism (Phe124Phe;...
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