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Article

p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate.

Journal of cell science - 15 Aug 2011

Watanabe Yoshihisa, Tanaka Masaki

Abstract excerpt

Proteolytic systems and the aggresome pathway contribute to preventing accumulation of cytotoxic aggregation-prone proteins. Although polyubiquitylation is usually required for degradation or aggresome formation, several substrates are processed independently of ubiquitin through a poorly understood mechanism. Here, we found that p62/SQSTM1, a multifunctional adaptor protein, was involved in the selective...

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Source

Identifiers

PMID: 21771882
DOI: 10.1242/jcs.081232

Genes

SQSTM1
HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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