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Article

Amyotrophic lateral sclerosis model derived from human embryonic stem cells overexpressing mutant superoxide dismutase 1.

Stem cells translational medicine - 1 May 2012

Wada Tamaki, Goparaju Sravan K, Tooi Norie, Inoue Haruhisa, Takahashi Ryosuke, Nakatsuji Norio, Aiba Kazuhiro

Abstract excerpt

The generation of amyotrophic lateral sclerosis (ALS) disease models is an important subject for investigating disease mechanisms and pharmaceutical applications. In transgenic mice, expression of a mutant form of superoxide dismutase 1 (SOD1) can lead to the development of ALS that closely mimics the familial type of ALS (FALS). Although SOD1 mutant mice show phenotypes similar to FALS, dissimilar drug responses...

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Identifiers

PMID: 23197818
DOI: 10.5966/sctm.2011-0061
PMCID: PMC3659703

Genes

SOD1

Variants

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