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Article

Role of Oxidative Stress in the Pathogenesis of Amyotrophic Lateral Sclerosis: Antioxidant Metalloenzymes and Therapeutic Strategies.

Biomolecules - 16 Mar 2021

Hemerková Pavlína, Vališ Martin

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) affects motor neurons in the cerebral cortex, brainstem and spinal cord and leads to death due to respiratory failure within three to five years. Although the clinical symptoms of this disease were first described in 1869 and it is the most common motor neuron disease and the most common neurodegenerative disease in middle-aged individuals, the exact etiopathogenesis of ALS...

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PMID: 33809730
DOI: 10.3390/biom11030437
PMCID: PMC8002298

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