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Article

Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer

1 Jun 2018

Abstract excerpt

Abstract: Several members of the sirtuin (SIRT) family, a highly conserved family of NAD + -dependent enzymes, have been shown to play a critical role in both promoting and/or suppressing tumorigenesis. In this study, recent progress in the field concerning SIRT4 and cancer was reviewed, and the relationship between SIRT4 and tumors was investigated. Subsequently, we evaluated the role of SIRT4 with oncogenic or...

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PMID: 29928130
DOI: 10.2147/ott.s157724

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