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Article

Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.

Cancer cell - 11 Feb 2013

Khandanpour Cyrus, Phelan James D, Vassen Lothar, Schütte Judith, Chen Riyan, Horman Shane R, Gaudreau Marie-Claude, Krongold Joseph, Zhu Jinfang, Paul William E, Dührsen Ulrich, Göttgens Bertie, Grimes H Leighton, Möröy Tarik

Abstract excerpt

Most patients with acute lymphoblastic leukemia (ALL) fail current treatments highlighting the need for better therapies. Because oncogenic signaling activates a p53-dependent DNA damage response and apoptosis, leukemic cells must devise appropriate countermeasures. We show here that growth factor independence 1 (Gfi1) can serve such a function because Gfi1 ablation exacerbates p53 responses and lowers the...

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Identifiers

PMID: 23410974
DOI: 10.1016/j.ccr.2013.01.011
PMCID: PMC3597385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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