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Article

Neuroadaptations in Human Chronic Alcoholics: Dysregulation of the NF-κB System

26 Sept 2007

Abstract excerpt

BACKGROUND: Alcohol dependence and associated cognitive impairments apparently result from neuroadaptations to chronic alcohol consumption involving changes in expression of multiple genes. Here we investigated whether transcription factors of Nuclear Factor-kappaB (NF-kappaB) family, controlling neuronal plasticity and neurodegeneration, are involved in these adaptations in human chronic alcoholics. METHODS AND...

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PMID: 17895971
DOI: 10.1371/journal.pone.0000930

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