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Article

The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis.

Developmental cell - 1 Oct 2001

Frank S, Gaume B, Bergmann-Leitner E S, Leitner W W, Robert E G, Catez F, Smith C L, Youle R J

Abstract excerpt

In healthy cells, fusion and fission events participate in regulating mitochondrial morphology. Disintegration of the mitochondrial reticulum into multiple punctiform organelles during apoptosis led us to examine the role of Drp1, a dynamin-related protein that mediates outer mitochondrial membrane fission. Upon induction of apoptosis, Drp1 translocates from the cytosol to mitochondria, where it preferentially...

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Identifiers

PMID: 11703942
DOI: 10.1016/s1534-5807(01)00055-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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