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Article

Genome-Wide Association Study: Functional Variant rs2076295 Regulates Desmoplakin Expression in Airway Epithelial Cells.

American journal of respiratory and critical care medicine - 1 Nov 2020

Hao Yuan, Bates Samuel, Mou Hongmei, Yun Jeong H, Pham Betty, Liu Jiangyuan, Qiu Weiliang, Guo Feng, Morrow Jarrett D, Hersh Craig P, Benway Christopher J, Gong Lu, Zhang Yihan, Rosas Ivan O, Cho Michael H, Park Jin-Ah, Castaldi Peter J, Du Fei, Zhou Xiaobo

Abstract excerpt

Rationale: Genetic association studies have identified rs2076295 in association with idiopathic pulmonary fibrosis (IPF). We hypothesized that rs2076295 is the functional variant regulating DSP (desmoplakin) expression in human bronchial epithelial cells, and DSP regulates extracellular matrix-related gene expression and cell migration, which is relevant to IPF development.Objectives: To determine whether...

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Share to Alveolar Epithelial Cells
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Source

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Identifiers

PMID: 32551799
DOI: 10.1164/rccm.201910-1958OC
PMCID: PMC7605184

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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