Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells

13 Jul 2022

Abstract excerpt

Genome-wide association studies (GWAS) have identified dozens of loci associated with chronic obstructive pulmonary disease (COPD) susceptibility; however, the function of associated genes in the cell type(s) affected in disease remains poorly understood, partly due to a lack of cell models that recapitulate human alveolar biology. Here, we apply CRISPR interference to interrogate the function of nine genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Neonatal Respiratory Health Research
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35857525
DOI: 10.1126/sciadv.abo6566

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cellsPMID 35857525Read ↗

Genome-Wide Association Study: Functional Variant rs2076295 Regulates Desmoplakin Expression in Airway Epithelial Cells.Semantic proximity Read ↗

The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cellsSemantic proximity Read ↗

A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells.Semantic proximity Read ↗

Syndecan-1 Promotes Alveolar Type 2 Epithelial Cell Senescence during Lung FibrosisSemantic proximity Read ↗

Loss of ANT1 Increases Fibrosis and Epithelial Cell Senescence in Idiopathic Pulmonary FibrosisSemantic proximity Read ↗

AT2-intrinsic Z-AAT expression drives conserved inflammatory and proteotoxic stress responses and predisposes to emphysemaSemantic proximity Read ↗

Human pluripotent stem cell modeling of alveolar type 2 cell dysfunction caused by ABCA3 mutations.Semantic proximity Read ↗

The SERPINE2 gene is associated with chronic obstructive pulmonary disease.Semantic proximity Read ↗

Reversing Mechanoinductive DSP Expression by CRISPR/dCas9–mediated Epigenome EditingSemantic proximity Read ↗

Epigenetic silencing of SOD2 exacerbates mitochondrial oxidative stress and promotes pulmonary fibrosisSemantic proximity Read ↗

Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells.Semantic proximity Read ↗

Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.