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Article

Methyl-CpG-binding protein 2 mediates antifibrotic effects in scleroderma fibroblasts.

Annals of the rheumatic diseases - 1 Aug 2018

He Ye, Tsou Pei-Suen, Khanna Dinesh, Sawalha Amr H

Abstract excerpt

OBJECTIVE: Emerging evidence supports a role for epigenetic regulation in the pathogenesis of scleroderma (SSc). We aimed to assess the role of methyl-CpG-binding protein 2 (MeCP2), a key epigenetic regulator, in fibroblast activation and fibrosis in SSc. METHODS: Dermal fibroblasts were isolated from patients with diffuse cutaneous SSc (dcSSc) and from healthy controls. MeCP2 expression was measured by qPCR and...

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Source

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Identifiers

PMID: 29760157
DOI: 10.1136/annrheumdis-2018-213022
PMCID: PMC7297461

Genes

NID2
PLAU
ADA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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