Article
BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia.
International journal of cancer - 1 Dec 2018
de Smith Adam J, Walsh Kyle M, Francis Stephen S, Zhang Chenan, Hansen Helen M, Smirnov Ivan, Morimoto Libby, Whitehead Todd P, Kang Alice, Shao Xiaorong, Barcellos Lisa F, McKean-Cowdin Roberta, Zhang Luoping, Fu Cecilia, Wang Rong, Yu Herbert, Hoh Josephine, Dewan Andrew T, Metayer Catherine, Ma Xiaomei, Wiemels Joseph L
Abstract excerpt
Genome-wide association studies of childhood acute lymphoblastic leukemia (ALL) have identified regions of association at PIP4K2A and upstream of BMI1 at chromosome 10p12.31-12.2. The contribution of both loci to ALL risk and underlying functional variants remain to be elucidated. We carried out single nucleotide polymorphism (SNP) imputation across chromosome 10p12.31-12.2 in Latino and non-Latino white ALL...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.