Article
Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by a CEBPE promoter polymorphism.
Leukemia - 1 Jan 2019
Studd James B, Yang Minjun, Li Zhenhua, Vijayakrishnan Jayaram, Lu Yi, Yeoh Allen Eng-Juh, Paulsson Kajsa, Houlston Richard S
Abstract excerpt
Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy. Genome-wide association studies have shown variation at 14q11.2 influences ALL risk. We sought to decipher causal variant(s) at 14q11.2 and the mechanism of tumorigenesis. We show rs2239630 G>A resides in the promoter of the CCAT enhancer-binding protein epsilon (CEBPE) gene. The rs2239630-A risk allele is associated with increased...
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