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Article

Genomic integrity in the male germ line: evidence in support of the disposable soma hypothesis.

Reproduction (Cambridge, England) - 1 Sept 2018

Xavier Miguel J, Mitchell Lisa A, McEwan Kristen E, Scott Rodney J, Aitken R John

Abstract excerpt

The Big Blue λSelect-cII selection system has been employed along with whole-exome sequencing to examine the susceptibility of the male germ line to mutation in two challenging situations (i) exposure to a chemotherapeutic regime including bleomycin, etoposide and cis-platinum (BEP) and (ii) the ageing process. A 3-week exposure to BEP induced complete azoospermia associated with a loss of developing germ cells...

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PMID: 29921625
DOI: 10.1530/REP-18-0202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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