Article
The senescence-accelerated mouse prone 8 as a model for oxidative stress and impaired DNA repair in the male germ line.
Reproduction (Cambridge, England) - 1 Sept 2013
Smith T B, De Iuliis G N, Lord T, Aitken R J
Abstract excerpt
The discovery of a truncated base excision repair pathway in human spermatozoa mediated by OGG1 has raised questions regarding the effect of mutations in critical DNA repair genes on the integrity of the paternal genome. The senescence-accelerated mouse prone 8 (SAMP8) is a mouse model containing a suite of naturally occurring mutations resulting in an accelerated senescence phenotype largely mediated by...
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