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Article

Age-related alterations in the genetics and genomics of the male germ line.

Fertility and sterility - 1 Feb 2017

Herati Amin S, Zhelyazkova Boryana H, Butler Peter R, Lamb Dolores J

Abstract excerpt

Paternal aging is associated with increased risk of genetic disease transmission to the offspring. The changes associated with aging arise predominantly through formation of single nucleotide variation through DNA replication errors, as well as possibly chronic exposure to environmental toxins and reactive oxygen species exposure. Several age-related reproductive factors are also contributory, including the...

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Source

Identifiers

PMID: 28160920
DOI: 10.1016/j.fertnstert.2016.12.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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