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Article

Environmental exposure of the mouse germ line: DNA adducts in spermatozoa and formation of de novo mutations during spermatogenesis.

PloS one - 28 Jun 2010

Olsen Ann-Karin, Andreassen Ashild, Singh Rajinder, Wiger Richard, Duale Nur, Farmer Peter B, Brunborg Gunnar

Abstract excerpt

BACKGROUND: Spermatozoal DNA damage is associated with poor sperm quality, disturbed embryonic development and early embryonic loss, and some genetic diseases originate from paternal de novo mutations. We previously reported poor repair of bulky DNA-lesions in rodent testicular cells. METHODOLOGY/PRINCIPAL FINDINGS: We studied the fate of DNA lesions in the male germ line. B[a]PDE-N(2)-dG adducts were determined...

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Identifiers

PMID: 20596530
DOI: 10.1371/journal.pone.0011349
PMCID: PMC2893163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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