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Article

Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 2018

Sonn Jun Young, Lee Jongbin, Sung Min Kyung, Ri Hwajung, Choi Jung Kyoon, Lim Chunghun, Choe Joonho

Abstract excerpt

Sleep and metabolism are physiologically and behaviorally intertwined; however, the molecular basis for their interaction remains poorly understood. Here, we identified a serine metabolic pathway as a key mediator for starvation-induced sleep suppression. Transcriptome analyses revealed that enzymes involved in serine biosynthesis were induced upon starvation in Drosophila melanogaster brains. Genetic mutants of...

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Identifiers

PMID: 29915051
DOI: 10.1073/pnas.1719033115
PMCID: PMC6142195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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