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Metabolic Alterations Induced by a Seizure-Causing Sodium Channel Mutation and their Partial Normalization by Dietary α-Linolenic Acid in Drosophila.

Neurochemical research - 20 Jan 2026

Kruth Karina, Kasuya Junko, Hand Victoria, Iyengar Atulya, Kitamoto Toshihiro

Abstract excerpt

Epilepsy is increasingly recognized as a disorder with prominent metabolic disturbances, but how defined epilepsy-causing mutations reshape metabolism under controlled genetic and environmental conditions remains poorly understood. Here, we used the Drosophila melanogaster gain-of-function voltage-gated sodium channel (VGSC) mutant paraShu, a well-established model of neuronal and behavioral hyperexcitability, to...

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Identifiers

PMID: 41557249
DOI: 10.1007/s11064-026-04673-2
PMCID: PMC12819498

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GC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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