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Article

Coordination between Drosophila Arc1 and a specific population of brain neurons regulates organismal fat.

Developmental biology - 15 Sept 2015

Mosher Jeremy, Zhang Wei, Blumhagen Rachel Z, D'Alessandro Angelo, Nemkov Travis, Hansen Kirk C, Hesselberth Jay R, Reis Tânia

Abstract excerpt

The brain plays a critical yet incompletely understood role in regulating organismal fat. We performed a neuronal silencing screen in Drosophila larvae to identify brain regions required to maintain proper levels of organismal fat. When used to modulate synaptic activity in specific brain regions, the enhancer-trap driver line E347 elevated fat upon neuronal silencing, and decreased fat upon neuronal activation....

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Identifiers

PMID: 26209258
DOI: 10.1016/j.ydbio.2015.07.021
PMCID: PMC4583068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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