Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Notch1 pathway in adrenocortical carcinomas: correlations with clinical outcome.

Endocrine-related cancer - 1 Aug 2015

Ronchi Cristina L, Sbiera Silviu, Altieri Barbara, Steinhauer Sonja, Wild Vanessa, Bekteshi Michaela, Kroiss Matthias, Fassnacht Martin, Allolio Bruno

Abstract excerpt

Previous SNP array analyses have revealed genomic alterations of the Notch pathway as being the most frequent abnormality in adrenocortical tumors (ACTs). The aim of the present study was to evaluate the expression of components of Notch signaling in ACTs and to correlate them with clinical outcome. The mRNA expression of JAG1, NOTCH1, and selected target genes of NOTCH1 (HES1, HES5, and HEY2) was evaluated in 80...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Adrenal Cortex Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adrenal Glands

Share to Adrenocortical Carcinoma

Share to Jagged-1 Protein

Share to Receptor, Notch1

Share to Serrate-Jagged Proteins

Share to Wnt Proteins

Source

Identifiers

PMID: 25979380
DOI: 10.1530/ERC-15-0163

Genes

HEY2
JAG1
NOTCH1
HES1
HES5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Notch1 pathway in adrenocortical carcinomas: correlations with clinical outcome.PMID 25979380Read ↗

Upregulated JAG1 Enhances Cell Proliferation in Adrenocortical CarcinomaSemantic proximity Read ↗

Microarray gene expression and immunohistochemistry analyses of adrenocortical tumors identify IGF2 and Ki-67 as useful in differentiating carcinomas from adenomasSemantic proximity Read ↗

Transcriptome analysis of adrenocortical cancers (ACC): from molecular classification to the identification of new treatmentsSemantic proximity Read ↗

Integrated genomic characterization of adrenocortical carcinoma.Semantic proximity Read ↗

Molecular Markers and the Pathogenesis of Adrenocortical CancerSemantic proximity Read ↗

Molecular Classification and Prognostication of Adrenocortical Tumors by Transcriptome ProfilingSemantic proximity Read ↗

Gene Expression Profiling Reveals a New Classification of Adrenocortical Tumors and Identifies Molecular Predictors of Malignancy and SurvivalSemantic proximity Read ↗

Adrenocortical cancer.Semantic proximity Read ↗

5th International ACC Symposium: Classification of Adrenocortical Cancers from Pathology to Integrated Genomics: Real Advances or Lost in Translation?Semantic proximity Read ↗

Five new hub genes that have an impact on the survival rate of adrenocortical carcinoma were discovered using a correlation network approach in a comprehensive meta-analysisSemantic proximity Read ↗

Therapeutic Targets for Adrenocortical Carcinoma in the Genomics EraSemantic proximity Read ↗

Integrated genome-wide analysis of genomic changes and gene regulation in human adrenocortical tissue samplesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.