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Article

Hypermethylation of E‐cadherin is an independent predictor of improved survival in head and neck squamous cell carcinoma

18 Aug 2008

Abstract excerpt

BACKGROUND: The loss of E-cadherin (ECAD) protein expression has been linked to aggressive head and neck squamous cell carcinoma (HNSCC). Promoter hypermethylation of the cadherin 1, type 1 (CDH1) gene (encoding ECAD) is 1 mechanism by which this protein can be inactivated, although this epigenetic alteration of the gene has not been linked conclusively to poorer patient outcome and, in fact, may be associated...

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PMID: 18711702
DOI: 10.1002/cncr.23770

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